22311.5.1.4 Interaction Between Stromal Cells and Cancer Stem Cells
Endothelial cell-secreted factors are reported to enhance the invasive migration and
resistance to anoikis in oral CSCs (Fig. 11.3) (Neiva et al. 2009 ). According to
recent study, endothelial cell-secreted EGF induced EMT via Snail induction
Fig. 11.4 Three compartment metabolism in tumor stroma. The non-proliferating cancer stem
cells rely on the mostly on OXPHOS instead of glycolysis. However, proliferating cancer stem
cells rely on both OXPHOS and glycolysis. The differentiated and proliferating non-stem cancer
cell relies only on glycolysis. Autophagy mediated generation of metabolites in the tumor stromal
and lactate shuttling process via the reverse Warburg effect offers metabolic coupling between the
tumor and the stromal cells
11 Oral Cancer Stem Cells Microenvironment