Organ Regeneration Based on Developmental Biology

139

Branching morphogenesis

Cell proliferatioBud and acini formationExtracellular matrixremodeling

n

Mesenchymal proliferation& condensation

Epitheliu

m

Mesenchy

me

Pax6 Foxc1

Sox9 Sox10

Barx

2

Bmp7

Genes

Proteins & molecules

Activation

Inhibition

Interactio

n

Fgf10

Fgfr2bCol2aCol9a Cell adhesionmoleculesMMPs

Cy

clinD1

Runx

1

Binding

Stalk elongation

Fig. 8.2

Schematic illustration of signaling pathways involving development of the lacrimal glands. Bmp7 (bone morphogenetic protein 7), Fgf10, fibroblast

growth factor 7, Fgfr2b, fgf10 receptor, Col (collagen), MMP (matrix metalloproteinase)

8 Functional Lacrimal Gland Regeneration