21Kumar A, Singh SK, Kumar V, Kumar D, Agarwal S, Rana MK (2015) Huntington’s disease: an
update of therapeutic strategies. Gene 556(2):91–97
Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger
JM, Jackson AP, Knoblich JA (2013) Cerebral organoids model human brain development and
microcephaly. Nature 501(7467):373–379
Lee KJ, Jessell TM (1999) The specification of dorsal cell fates in the vertebrate central nervous
system. Annu Rev Neurosci 22(1):261–294
Lee SM, Tole S, Grove E, McMahon AP (2000) A local Wnt-3a signal is required for development
of the mammalian hippocampus. Development 127(3):457–467
Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES (2013) The
choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy.
J Neurosci 33(45):17553–17559
Letinic K, Zoncu R, Rakic P (2002) Origin of GABAergic neurons in the human neocortex. Nature
417(6889):645–649
Levine AJ, Brivanlou AH (2007) Proposal of a model of mammalian neural induction. Dev Biol
308(2):247–256
Li XJ, Zhang X, Johnson MA, Wang ZB, LaVaute T, Zhang SC (2009) Coordination of sonic
hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from
human embryonic stem cells. Development 136(23):4055–4063
Lui JH, Hansen DV, Kriegstein AR (2011) Development and evolution of the human neocortex.
Cell 146(1):18–36
Lumsden A, Krumlauf R (1996) Patterning the vertebrate neuraxis. Science
274(5290):1109–1115
Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J, Liu Z, Cai Y, Liu F, You Y, Chen
C, Campbell K, Song H, Ma L, Rubenstein JL, Yang Z (2013) Subcortical origins of human and
monkey neocortical interneurons. Nat Neurosci 16:1588–1597
Mangale VS, Hirokawa KE, Satyaki PR, Gokulchandran N, Chikbire S, Subramanian L, Shetty
AS, Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S, Monuki ES (2008) Lhx2 selec-
tor activity specifies cortical identity and suppresses hippocampal organizer fate. Science
319(5861):304–309
Mariani J, Simonini MV, Palejev D, Tomasini L, Coppola G, Szekely AM, Horvath TL, Vaccarino
FM (2012) Modeling human cortical development in vitro using induced pluripotent stem
cells. Proc Natl Acad Sci USA 109(31):12770–12775
Marı́n O, Anderson SA, Rubenstein JL (2000) Origin and molecular specification of striatal inter-
neurons. J Neurosci 20(16):6063–6076
Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG,
Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L (2013) Directed
differentiation and functional maturation of cortical interneurons from human embryonic stem
cells. Cell Stem Cell 12(5):559–572
Miyata T, Kawaguchi A, Okano H, Ogawa M (2001) Asymmetric inheritance of radial glial fibers
by cortical neurons. Neuron 31(5):727–741
Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD (2007) Neuronal subtype specification in the
cerebral cortex. Nat Rev Neurosci 8(6):427–437
Monuki ES, Porter FD, Walsh CA (2001) Patterning of the dorsal telencephalon and cerebral cor-
tex by a roof plate-Lhx2 pathway. Neuron 32(4):591–604
Muhr J, Graziano E, Wilson S, Jessell TM, Edlund T (1999) Convergent inductive signals specify
midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos. Neuron
23(4):689–702
Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai
Y (2012) Robust formation and maintenance of continuous stratified cortical neuroepithelium
by laminincontaining matrix in mouse ES cell culture. PLoS One 7:e53024
Nery S, Fishell G, Corbin JG (2002) The caudal ganglionic eminence is a source of distinct cortical
and subcortical cell populations. Nat Neurosci 5(12):1279–1287
1 Telencephalic Tissue Formation in 3D Stem Cell Culture