Imaging in Stem Cell Transplant and Cell-based Therapy

163

Table 10.2

In vivo studies and clinical trials employing human EnSCs

In vivo studiesDisease model

Mode of administration

Animal model

Outcome

References

Cardiac regeneration

DMD

Intramuscular

DMD mouse

Recovery of dystrophin expression and subsequent muscle repair

[^44

]

MI

Intra-myocardial

Nude rat

Transdifferentiation into cardiac cells and restoration of cardiac function

[^45

]

MI

Intra-myocardial

Mouse

Improvement of myocardial function

[^53

]

Neural regeneration

MI

Intravenous

Rat

Homing to the injured myocardium, tissue repair and prevention of cardiac dysfunction

[^54

]

Stroke

Intracerebral, intravenous

Rat

Significant reduction in behavioural and histological abnormalities of stroke

[^50

]

Pancreatic regeneration

Multiple sclerosis

Intraperitoneal

Mouse

Reduced EAE score; upregulated levels of anti-inflammatory cytokines

[^55

]

Parkinson’s disease

Intrastriatal

Primate

Development of neuron-like morphology; expression of tyrosine hydroxylase

[^56

]

Diabetes

Renal subcapsular injection

SCID mouse

Blood glucose levels were stabilized within 5 weeks

[^51

]

Diabetes

Renal subcapsular injection

SCID mouse

Blood insulin levels restored with prolonged survival of graft cells

[^52

]

Tissue engineering

Scaffold

Animal model

Outcome

References

Gelatin-coated polyamide knit

Rat model of wound healing

↑ Neovascularization, tissue integration, collagen fibres, distensibility of the mesh;

↓chronic inflammation, fibrosis

[^1

]

Biomimetic gelatin/apatite scaffolds

Rat model of bone regeneration

↑ Bone formation and maturation

[^57

]

(continued)

10 Uterine Stem Cells and Their Future Therapeutic Potential in Regenerative Medicine