EFFECTS ON IMMUNE RESPONSE 97
Table 5.1. Select Characteristics of T and B Cells
T Cells
B Cells
Cell of origin
Hematopoietic stem cell
Hematopoietic stem cell
Site of maturation
Thymus
Bursa Fabricius (birds);bone marrow (mammals)
Function
Regulatory (help, suppression) and
Precursor of antibody-
effector (delayed-type hypersensitivity,
producing cell
mixed lymphocyte reaction, cytotoxic or “ killer”)
Primary anatomic localization
— Spleen
Periarteriolar cuff
Follicles
— Lymph node
Para-cortex
Primary follicles
— Peyer’s patch
Interfollicular
Follicles
Recirculating pool
Majority (80-85% in mouse)
Minority (15-20% in mouse)
Life span
4-6 months
6-8 weeks
Mitogenic response
PHA, Con A
LPSPurified protein derivative
Memory
Yes
Yes
Source:
After Anderson et al.11