Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)

154 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES

O-methylguanine acceptor, 55
repair of, 46
stress protein, 41-48
ultraviolet spectrum of, 45
Publication bias, 134
Public health, 64, 84-85
Puromycin, 45
Pyrazole, 63

Qualitative risk-benefit evaluation,
119-137
meta-analytic methods in, 134-137
standardized ratios in, 125-134
two-by-two tables in, 120-125
Quantitative dose-response models,
137-142
Quinones, 60

Radiation, 41. See also specific types

carcinogenesis and, 114

cytotoxic actions of, 60

dosage of, 32

electromagnetic, 41

gamma, 15, 21, 22, 41

immune response to. See Immune

response

immunosuppressive effects of, 101

ionizing, 8, 30, 41, 46, 85, 101

repair of damage from, 54

sensitivity to, 45

sensitivity to chemical agents and,

56

toxicity of, 21

ultraviolet, 41, 44, 45, 46, 54, 55

X, 15, 29-30, 45, 54

Rate theory approach to mortality

data, 2

Recirculation pool, 99

Redox cycling quinones, 60

Reduced caloric intake. See Caloric

restriction

Refolding, 46

Regeneration, 60, 69, 70, 71, 74

Regression analysis, 18

Regulatory T-cells, 98

Regulons, 44

Relative risk, 134

Repair, 46

adaptive, 139-140

DNA, 45, 53-56

first-order rate constant for, 7

protein, 46

tissue, 60

cellular proliferation and, 81

mechanism of, 82

stimulation of, 67-74

early-phase, 73-79

Resilency, 76

Resistance, 42, 68

Retinoic acid, 47

Retrotransposition, 45-46

Risk assessment, 4, 21, 126-127,

128-129, 134

RNA viruses, 114, 115

RR. See Relative risk

Saturated fats, 6

Second law of thermodynamics, 2, 5

Selegiline (deprenyl), 9

Senescence, 2, 5, 6, 7-10

Serum cholesterol, 10

Sheep red blood cells (SRBCs), 103,

104

Sigmoid Emax model

(logarithmic-logistic function), 13

SIR. See Standardized incidence ratio

SKF-525A, 63

SMR. See Standardized mortality

ratio

SOS response, 44, 45

Sporulation, 46

SR. See Standardized ratios

SRBCs. See Sheep red blood cells

Standardized incidence ratio (SIR),

125

Standardized mortality ratio (SMR),

30, 32, 125

Standardized ratios, 125, 125-134

Stochastic two-stage models, 142

Stress, 9. See also specific types

Stressors, 41-43, 42, 46. See also

specific types

Stress protein response, 41-48

defined, 41

paradox of, 47-48

Superimposition, 7-8

Suppressor cells, 103, 105

Survivalship function, 19