Drug Metabolism in Drug Design and Development Basic Concepts and Practice

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Sonoda J, Xie W. et al. Regulation of a xenobiotic sulfonation cascade by nuclear
pregnane X receptor (PXR). Proc Natl Acad Sci U S A 2002;99(21):13801–13806.
Sorensen M, Autrup H, Tjonneland A, Overvad K, Raaschou-Nielsen O. Glutathione
S-transferase T1 null-genotype is associated with an increased risk of lung cancer. Int
J Cancer 102004;110(2):219–224.
Soucy NV, Parkinson HD. et al. Kinetics of genistein and its conjugated metabolites in
pregnant sprague–dawley rats following single and repeated genistein administration.
Toxicol Sci 2005.
Stern ST, Bruno MK, Hennig GE, Horton RA, Roberts JC, Cohen SD. Contribution of
acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I.
Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine.
Toxicol Appl Pharmacol 152005;202(2):151–159.
Tetlow N, Liu D, Board P. Polymorphism of human Alpha class glutathione
transferases. Pharmacogenetics 2001;11(7):609–617.
Tong Z, Board PG, Anders MW. Glutathione transferase zeta-catalyzed biotransfor-
mation of dichloroacetic acid and other alpha-haloacids. Chem Res Toxicol
1998;11(11):1332–1338.
Trapnell CB, Klecker RW. et al. Glucuronidation of 3’-azido-3’-deoxythymidine
(zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic
interactions with atovaquone, fluconazole, methadone, and valproic acid.
Antimicrob Agents Chemother 1998;42(7):1592-1596.
van der Woude H, Boersma MG. et al. Identification of 14 quercetin phase II mono-
and mixed conjugates and their formation by rat and human phase IIin vitromodel
systems. Chem Res Toxicol 2004;17(11):1520–1530.
Varin L, Barron D. et al. Enzymatic assay for flavonoid sulfotransferase. Anal Biochem
1987;161(1):176–180.
Vietri M, Pietrabissa A. et al. Differential inhibition of hepatic and duodenal sulfation
of ()-salbutamol and minoxidil by mefenamic acid. Eur J Clin Pharmacol
2000;56(6–7):477–479.
Vietri M, Vaglini F. et al. Sulfation ofR()-apomorphine in the human liver and
duodenum, and its inhibition by mefenamic acid, salicylic acid and quercetin.
Xenobiotica 2002;32(7):587–594.
Warholm M, Guthenberg C, Mannervik B. Molecular and catalytic properties of
glutathione transferase mu from human liver: an enzyme efficiently conjugating
epoxides. Biochemistry 191983;22(15):3610–3617.
Weinshilboum RM, Otterness DM. et al. Sulfation and sulfotransferases 1:
sulfotransferase molecular biology: cDNAs and genes. FASEB J 1997;11(1):3–14.
Zhang D, Zhao W, Roongta V, Mitroka J, Klunk L, Zhu M. Amide N-glucuronidation
of maxipost catalyzed by UGP-glucuronosyltransferase 2B7 in humans. Drug Metab
Dispos 2004;32:545-551.
Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG. In vitro
inhibition of UDP glucuronosyltransferases by atazanavir and other protease
inhibitors and the relationship of this properties to in vivo bilirubin glucuronidation.
Drug Metab Dispos 2005;33:1729-1739.
Zheng W, Xie D. et al. Sulfotransferase 1A1 polymorphism, endogenous estrogen
exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol
Biomarkers Prev 2001;10:89–94.


88 CONJUGATIVE METABOLISM OF DRUGS

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