Drug Metabolism in Drug Design and Development Basic Concepts and Practice

TABLE 6.1 (

Continued

)

Gene

Protein name

Tissue distribution

Substrate properties

Selected inhibitor

and (inducer)

Driving force

SLC28A2

CNT2

Kidney, heart, liver,

skeletal muscle,pancreas, placenta,brain, cervix,prostate, smallintestine, rectum,colon, lung

Pyrimidine nucleosides,

adenosine

Na

+

free buffer

SLC28A3

CNT3

Mammary gland,

pancreas, bonemarrow, trachea,intestine, liver, lung,placenta, prostate,testis, brain, heart

Nucleosides and

nucleoside analogues

Na

+

free buffer

146