de Groot MJ, Ekins S. Pharmacophore modeling of cytochromes P450. Adv Drug Deliv
Rev 2002;54:367–383.
Dieckhaus CM, Fernandez-Metzler CL, King R, Krolikowski PH, Baillie TA. Negative
ion tandem mass spectrometry for the detection of glutathione conjugates. Chem Res
Toxicol 2005;18:630–638.
Egnash LA, Ramanathan R. Comparison of heterogeneous and homogeneous
radioactivity flow detectors for simultaneous profiling and LC-MS/MS characteriza-
tion of metabolites. J Pharm Biomed Anal 2002;27:271–284.
Ekins S, Andreyev S, Ryabov A, Kirillov E, Rakhmatulin EA, Bugrim A, Nikolskaya
T. Computational prediction of human drug metabolism. Expert Opin Drug Metab
Toxicol 2005;1:303–324.
Ekins S, Obach RS. Three-dimensional quantitative structure activity relationship
computational approaches for prediction of human in vitrointrinsic clearance.
J Pharmacol Exp Ther 2000;295:463–473.
Erhardt PW. A human drug metabolism database: potential roles in the quantitative
predictions of drug metabolism and metabolism-related drug–drug interactions. Curr
Drug Metab 2003;4:411–422.
Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Drug-protein adducts: an industry
perspective on minimizing the potential for drug bioactivation in drug discovery and
development. Chem Res Toxicol 2004;17:3–16.
Fisher MB, Campanale K, Ackermann BL, VandenBranden M, Wrighton SA.In vitro
glucuronidation using human liver microsomes and the pore-forming peptide
alamethicin. Drug Metab Dispos 2000;28:560–566.
Fisher MB, Yoon K, Vaughn ML, Strelevitz TJ, Foti RS. Flavin-containing
monooxygenase activity in hepatocytes and microsomes:in vitrocharacterization
and in vivo scaling of benzydamine clearance. Drug Metab Dispos 2002;30:
1087–1093.
Fura A. Role of pharmacologically-active metabolites in drug discovery and
development. Drug Discov Today 2006;11:133–142.
Fura A, Shu YZ, Zhu M, Hanson RL, Roongta V, Humphreys WG. Discovering drugs
through biological transformation: role of pharmacologically active metabolites in
drug discovery. J Med Chem 2004;47:4339–4351.
Gan J, Harper TW, Hsueh MM, Qu Q, Humphreys WG. Dansyl glutathione as a
trapping agent for the quantitative estimation and identification of reactive
metabolites. Chem Res Toxicol 2005;18:896–903.
Grime K, Riley RJ. The impact ofin vitrobinding onin vitro–in vivoextrapolations,
projections of metabolic clearance and clinical drug-drug interactions. Curr Drug
Metab 2006;7:251–264.
Guengerich FP. Common and uncommon cytochrome P450 reactions related to
metabolism and chemical toxicity. Chem Res Toxicol 2001;14:611–650.
Guengerich FP. Cytochrome P450 oxidations in the generation of reactive electrophiles:
epoxidation and related reactions. Arch Biochem Biophys 2003;409:59–71.
Guengerich FP. Principles of covalent binding of reactive metabolites and examples of
activation of bis-electrophiles by conjugation. Arch Biochem Biophys 2005;433:
369–378.
REFERENCES 255