Drug Metabolism in Drug Design and Development Basic Concepts and Practice

FIGURE 16.3 CYP inhibition curves of six known chemical inhibitors in the metabolism
of marker substrates at theirKmvalues by human liver microsomes using Equation 16.2
(Yao et al., 2007).

and the resulting IC 50 values, respectively, which were consistent with those in
literature.

n¼

Vo

1 þ

½IŠ

IC 50

s ð 16 : 2 Þ

REVERSIBLE INHIBITION 525