TABLE 17.2 Summary of Human PXR reporter gene assays used in several laboratories.Author
PXR Construct
Reporter gene construct
Cell line
Maximal induction
References
Bertilsson et al
GAL
4–LBD
4USA-Luciferase
Caco-2
15-fold
Bertilsson et al., (1998)
pCMV
–PXR
CYP3A4(ER)6-Luciferase
Caco-2
5-fold
Blumberg et al
GAL
–LBD
Tk-USA-Luciferase
CV-1
12-fold
Blumberg et al., (1998)
pSG
5–PXR
Tk-(ER)6-Luciferase
CV-1
12-fold
Lehmann et al
pSG
5–PXR
(ER)6-tk-CAT
CV-1
9-fold
Lehmann et al., (1998)
Goodwin et al
pSG
5–PXR
CYP3A4(
7836 to 208)
(
362 to 53)-Luciferase
HepG2
40-fold
Goodwin et al., (1999)
El-Sankary et al
pSG
5–PXR
CYP3A4(
1087 to
57)-SPAP
HepG2
3-fold
El-Sankary et al., (2000)
561