Drug Metabolism in Drug Design and Development Basic Concepts and Practice

0

500

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0

25

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75

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Rat

Dog

Monkey

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P

P

M11

M5 M10

M15

M15

HPLC time (min)

CPM

M5 M20

M20 M15

M18

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Human

P

M13 M15

M10

M18 M5

M11

FIGURE 18.2 Radiochromatograms of pooled plasma samples (1 h) after an oral
administration of [^14 C]muraglitazar to rats, dogs, monkeys, and humans (P = parent)

590 ADME STUDIES IN ANIMALS AND HUMANS