TABLE 3.1 UGT1A nomenclature:seehttp://som.flinders.edu.au/FUSA/
ClinPharm/UGT/.
UGT1
gene
Trivial
names
Endogenous
substrates
Tissue
expression Comments
UGT1A1 Rat B1
HUGBr-1
Bilirubin
Estradiol
(3-OH)
Liver, intestine,
mammary
gland
Polymorphic
regulation
UgtBr1
(mouse)
Morphine
(3-OH)
Catechol
estrogens
(2OH>4OH)
Retinoic acid
leukotriene B4
12 and 15-HETE
13-HODE
Defective
genesCrigler–
Najjar
syndrome
Lowered
expression
Gilbert’s
syndrome
Trans-retinoic
acid is a
substrate for
rat UGT1A1
but not human?
UGT1A2 Rat B2 Bilirubin Pseudogene in
humans
Rapidly declines
in tissue
culture of rat
hepatocytes
UGT1A3 Bile acid Liver, intestine,
Catechol testes, prostate
estrogens
(2OH>4OH)
leukotriene B4
12 and 15-HETE
13-HODE
UGT1A4 HP3
HUGBr-2
12 and 15-HETE
13-HODE
Liver, intestine Pseudogene in
rats and mice
UGT1A6 HP1
HlugP1
Ugt1-6
Rat4NP
Liver, kidney,
intestine, brain,
ovary, testes
Pseudogene
in cats
Spleen, skin Polymorphic in
humans
UGT1A7 A2
1g
Gastric epithelium
esophagus
UGT1A8 Leukotriene B4 Intestine,
esophagus
UGT1A9 HP4 Catechol
estrogens
(4OH>2OH)
estradiol (low)
12 and 15-HETE
13-HODE
Liver, kidney ovary,
testes
Spleen, skin,
esophagus
UGT1A10 Intestine, lung
UGT1A11-
1A13
Pseudogenes
UDP-GLUCURONOSYLTRANSFERASES 43