Carboxyl group
: clofibrate,
ciprofibrate, etodolac,fenoprofen, ibuprofen,ketoprofen, naproxen(racemic
>
S), valproic
acid and formation ofsimvastatin and atorvastatinlactones via an intermediateacyl glucuronide
UGT1A4
Estrogens:
2-hydroxy-estrone and 2-hydroxy
estradiol, 4-hydroxy catechol estrogens (low),estriol,
Progestins
:5
a-pregnan-3
a,20
a
-diol,
16
a
-hydroxy pregennolone, 19- hydroxy and
21- hydroxy pregnenolone, pregneneolone,androsterone, epiandrosterone, etiocholanone,Androgens:
dehydroepiandrosterone,
dihydrotestosterone, epitestosterone,testostereone, 5
a-androstan-3
a,17
b-diol,
5 b
-androstan-3
a,11
a,17
b-triol; bilirubin
(very low), F
-1 6
a,23S,25(OH)
D 3
3
a
hexafluorinated Vit D
3
analog
Trifluoperazine:
6 m
M
(Ebner, 1993)
Hecogenin: 10
mM
(Uchaichipat, 2006;Green, 1998)
Tertiary amines:
amitriptyline,
chlorpheniramine,chlorpromazine,clozapine, cyproheptadine,diphenylamine, doxepin,imipramine, ketotifen,loxapine, promethazine,tripellenamine,trifluoperazine
Aromatic heterocyclic amines:
croconazole, lamotrigine,nicotine (30X velocity thanUGT1A3), 1-phenylimidazole,posaconazole, retigabine
phenobarbital,
phenytoin, andcarbamazepine
Primary and secondary amines
:
2- and 4-aminobiphenyl,diphenylamine,desmethylclozapine
Alcoholic and phenolic substrates:
borneol, carveol, carvacroldiosgenin,
hecogenin
,
isomenthol, menthol,neomenthol, 1- and 2-naphthol(low),
p-nitrophenol (low),
nopol, tigogenin
47
(continued
)