Bile acids:
hyodexycholic acid
Estrogens:
Estriol, estradiol
(17
b-hydroxy), 4-hydroxy estrone
(high) 2- hydroxy estrone,2- hydroxy estriol
Pregnanes:
3 a
-hydroxy pregnanes,
Androgens:
3 a
-, 16
a-, 17
b-androgens,
Others:
5 a
- and
5 b
-dihydroaldosterone,
trans-retinoic acid,
Carboxylic acid-containing drugs:
benoxaprofen, ciprofibrate, clofibricacid, diflunisal, dimethylxanthenone-4-acetic acid (DMXAA), fenoprofen,ibuprofen, indomethacin, ketoprofen,naproxen, pitavastatin, simvastatinacid, tiaprofenic acid,valproic acid, zaltoprofen, zomepirac.
Opioids:
morphine 3OH
>
6OH,
buprenorphine, nalorphine,naltrexone, codeine (low)and naloxone.
UGT2B8UGT2B9 C18, C19, C20 steroids,
fatty acids (C6–C12)
Morphine
UGT2B10 No known substratesUGT2B11 No known substratesUGT2B12UGT2B13
17
b-Estradiol
(low)
4-Hydroxy biphenyl
4-Hydroxy
biphenyl(competitive)
UGT2B14
Estriol
UGT2B15
Testosterone
,
dihydrotestosterone
S-oxazepam:
30
mM (Court, 2002)
UGT2B16UGT2B17
Testosterone
, androsterone
UGT2B18UGT2B19UGT2B20UGT2B21
55