324 The Cell Language Theory: Connecting Mind and Matterb2861 The Cell Language Theory: Connecting Mind and Matter “6x9”of mRNA data using the original number n is referred to as the “absolute
method”, while that using the n(n - 1)/2 values as the “difference method”
in Figure 7.21.
The difference method of constructing the mRNA histogram was used
in analyzing the 50 ORFs encoding the KIAA pathway and the resulting
A vs. C plots are shown in Figure 7.22. When the drug-induced changes
in the slope of the A vs. C graphs are plotted against the average SMs of
the short, intermediate, and long surviving groups, a reasonable linear cor-
relation with a negative slope was found (see the bottom panel in Figure
7.22), indicating that the proteins encoded by the KIAA pathway is harm-
ful to breast cancer patients when averaged over five patients.Figure 7.21 The absolute (old; n) vs. difference (new; n(n - 1)/2) methods for construct-
ing histograms.LJсͲϬ͘ϬϮκΘdžнρ͘κκϳς
Ϭ ZϸсϬ͘ςςϬϭϮκςϬϮϬκϬςϬΘϬ ϭϬϬCACGI protein 5 Short Survivors (BE)
old methody = 0.0985x + 2.1307
Ϭ R² = 0.963 1ϮκςϬρϭϬ ϭρ ϮϬ ϮρCACGI protein 5 Short Survivors (BE)
new methody = 0.0013x + 4.9887
R² = 0.128 255.015.025.035.045.055.065.075.08010203040CACGI protein 6 Long Survivors (AF) old methodLJсϬ͘ϬςϯϯdžнϮ͘κϭκϭ
0 ZϸсϬ͘εϳϭΘ246010203040CCGI protein 6 Long Survivors (AF)
new methody = 0.0353x + 3.988 7
R² = 0.4834.44.64.855.2010203040CADFKZP protein 5 Short Survivors (BE)
old methody = 0.0879x + 2.3186
R² = 0.9803012340510 15 20CADFKZP proteins 5 Short Survivors (BE)
new methodb2861_Ch-07.indd 324 17-10-2017 12:06:42 PM