Antitumor Effects of Lithium Carbonate 9later developed lithium-induced hyperparathyroidism, but cessation of lithium
treatment normalized parathyroid function. The pathogenic mechanism for
parathyroid dysfunction in lithium-treated patients is still unclear [35].
CONCLUSION
Development of novel and efficient treatment strategies for epithelial
cancers, particularly gastrointestinal tract cancers and hepatocarcinoma has
vital importance considering their treatment refractoriness and very high
mortality. The understanding from different forms of lithium carbonate
interactions with the tumor cells, tumor environment cells and cellular targets
that have been identified may provide leads for the rise of effectiveness
antitumor therapy.
REFERENCES
[1] Malhi, G; Tanious, M; Das, P; Coulston, C; Berk, M. Potential
Mechanisms of Action of Lithium in Bipolar Disorder: Current
Understanding. CNS Drugs, 2013, 27(2), 135-53.
[2] Pottegård, A; Ennis, ZN; Hallas, J; Jensen, BL; Madsen, K; Friis, S.
Long-term use of lithium and risk of colorectal adenocarcinoma: a
nationwide case–control study. British Journal of Cancer, 2016, 114,
571 - 5.
[3] Kessing, LV; Gerds, TA; Feldt-Rasmussen, B; Andersen, PK; Licht,
RW. Lithium and renal and upper urinary tract tumors - results from a
nationwide population-based study. Bipolar Disorder, 2015, 8, 805-13.
[4] Maurer, U; Preiss, F; Brauns-Schubert, P; Schlicher, L; Charvet, C.
GSK- 3 - at the crossroads of cell death and survival. J. Cell. Sci., 2014,
127, 1369–1378.
[5] Bgatova, NP; Makarova, OP; Pozhidayeva, AA; Borodin, YI;
Rachkovskaya, LN; Konenkov, VI. Biological effects of lithium nano-
scaled particles. Achiev. Life Sci., 2012, 5, 29– 46 [Article in Russian].
[6] Negulyaev, YA; Vedernikova, EA. Sodium-selective channels in
membranes of rat macrophages. J Membr Biol., 1994, 138(1), 37-45.