In: Advances in Medicine and Biology. Vol. 107 ISBN: 978 - 1 - 53610 - 056 - 3
Editor: Leon V. Berhardt © 201 6 Nova Science Publishers, Inc.
Chapter 2
EPIGENETIC MODIFICATIONS IN TUMOR
SUPPRESSOR GENES (TSG): ITS
CONTRIBUTION TO TUMOR DEVELOPMENT
AND ITS CLINICAL RELEVANCE
R. Macri^1 , M. Costilla^1 , A. Klecha1,2, G. Cremaschi1,2
and M. L. Barreiro Arcos1,3,
(^1) Institute of Biomedical Investigations, National Scientific and Technical
Research Council (CONICET), Faculty of Medical Sciences, Pontificia
Universidad Católica Argentina (UCA);
(^2) Laboratory of Radioisotopes, Faculty of Pharmacy and Biochemistry,
Universidad de Buenos Aires (UBA), Buenos Aires, Argentina;
(^3) Department of Biological Chemistry, Faculty of Natural Sciences,
Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
ABSTRACT
Tumor development is the result of genetic and epigenetic
alterations. The epigenetic mechanisms do not imply a change in the
DNA sequence but can be as important as the genetic mechanisms for the Corresponding author: Maria Laura Barreiro Arcos, BIOMED-UCA-CONICET, Av. Alicia
Moreau de Justo 1600, 3rd floor, C1107AAZ, Ciudad Autónoma de Buenos Aires,
Argentina, Tel: +54 11 43490200 ext 1236, Fax: +54 11 43490200 ext 1263, E-mail:
[email protected].