Human Physiology, 14th edition (2016)

(Tina Sui) #1

358 Chapter 11



  1. If a person has a 50% reduction in insulin sensitivity, what
    happens to insulin release for the person to remain in the
    normal curve?

  2. If a person has a 50% increase in insulin sensitivity, what
    happens to insulin release for the person to remain in the
    normal curve?

  3. A person has impaired glucose tolerance despite having an
    insulin secretion 50% greater than normal. What range of
    values must be true of the person’s insulin sensitivity?

  4. A person has impaired glucose tolerance despite having an
    insulin sensitivity 50% greater than average. What range of
    values must be true of the person’s insulin release?


Test Your Quantitative Ability


In the graph below, insulin sensitivity is plotted on the x -axis
and insulin release on the y -axis, using arbitrary units where
1.0 represents average normal values for each measurement.
Individuals with points anywhere in the curved graph line
within the green area are considered normal. IGT  5  impaired
glucose tolerance, indicated by the yellow area of the graph;
T2DM  5  type 2 diabetes mellitus, indicated by the red area of
the graph.


2.0

1.0

0
0 0.5 1.0 1.5 2.0 2.5
Insulin sensitivity

0.5 IGT
T2DM

Normal

Insulin release

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