AMP-activated protein kinase (AMPK) is asso-
ciated with enhancement of Glut1-mediated
glucose transport. Arch Biochem Biophys 380
(2):347–352.https://doi.org/10.1006/abbi.
2000.1935
- Weisova P, Concannon CG, Devocelle M,
Prehn JH, Ward MW (2009) Regulation of
glucose transporter 3 surface expression by
the AMP-activated protein kinase mediates tol-
erance to glutamate excitation in neurons. J
Neurosci 29(9):2997–3008.https://doi.org/
10.1523/JNEUROSCI.0354-09.2009 - Marsin AS, Bertrand L, Rider MH, Deprez J,
Beauloye C, Vincent MF, Van den Berghe G,
Carling D, Hue L (2000) Phosphorylation and
activation of heart PFK-2 by AMPK has a role
in the stimulation of glycolysis during ischae-
mia. Curr Biol 10(20):1247–1255 - Jager S, Handschin C, St-Pierre J, Spiegelman
BM (2007) AMP-activated protein kinase
(AMPK) action in skeletal muscle via direct
phosphorylation of PGC-1alpha. Proc Natl
Acad Sci U S A 104(29):12017–12022.
https://doi.org/10.1073/pnas.0705070104 - Corazao-Rozas P, Guerreschi P, Jendoubi M,
Andre F, Jonneaux A, Scalbert C, Garcon G,
Malet-Martino M, Balayssac S, Rocchi S,
Savina A, Formstecher P, Mortier L, Kluza J,
Marchetti P (2013) Mitochondrial oxidative
stress is the Achille’s heel of melanoma cells
resistant to Braf-mutant inhibitor. Oncotarget
4(11):1986–1998. https://doi.org/10.
18632/oncotarget.1420 - Corazao-Rozas P, Guerreschi P, Andre F,
Gabert PE, Lancel S, Dekiouk S, Fontaine D,
Tardivel M, Savina A, Quesnel B, Mortier L,
Marchetti P, Kluza J (2016) Mitochondrial oxi-
dative phosphorylation controls cancer cell’s
life and death decisions upon exposure to
MAPK inhibitors. Oncotarget 7
(26):39473–39485. https://doi.org/10.
18632/oncotarget.7790 - Rogers GW, Brand MD, Petrosyan S, Ashok D,
Elorza AA, Ferrick DA, Murphy AN (2011)
High throughput microplate respiratory mea-
surements using minimal quantities of isolated
mitochondria. PLoS One 6(7):e21746.
https://doi.org/10.1371/journal.pone.
0021746 - Schuh RA, Clerc P, Hwang H, Mehrabian Z,
Bittman K, Chen H, Polster BM (2011) Adap-
tation of microplate-based respirometry for
hippocampal slices and analysis of respiratory
capacity. J Neurosci Res 89(12):1979–1988.
https://doi.org/10.1002/jnr.22650 - Marinangeli C, Didier S, Vingtdeux V (2016)
AMPK in neurodegenerative diseases:
implications and therapeutic perspectives.
Curr Drug Targets 17(8):890–907
- Vingtdeux V, Davies P, Dickson DW, Maram-
baud P (2011) AMPK is abnormally activated
in tangle- and pre-tangle-bearing neurons in
Alzheimer’s disease and other tauopathies.
Acta Neuropathol 121(3):337–349.https://
doi.org/10.1007/s00401-010-0759-x - van Hall G, Stromstad M, Rasmussen P,
Jans O, Zaar M, Gam C, Quistorff B, Secher
NH, Nielsen HB (2009) Blood lactate is an
important energy source for the human brain.
J Cereb Blood Flow Metab 29(6):1121–1129.
https://doi.org/10.1038/jcbfm.2009.35 - Belanger M, Allaman I, Magistretti PJ (2011)
Brain energy metabolism: focus on astrocyte-
neuron metabolic cooperation. Cell Metab 14
(6):724–738. https://doi.org/10.1016/j.
cmet.2011.08.016 - Domise M, Didier S, Marinangeli C, Zhao H,
Chandakkar P, Buee L, Viollet B, Davies P,
Marambaud P, Vingtdeux V (2016)
AMP-activated protein kinase modulates tau
phosphorylation and tau pathology in vivo.
Sci Rep 6:26758.https://doi.org/10.1038/
srep26758 - Turban S, Stretton C, Drouin O, Green CJ,
Watson ML, Gray A, Ross F, Lantier L,
Viollet B, Hardie DG, Marette A, Hundal HS
(2012) Defining the contribution of
AMP-activated protein kinase (AMPK) and
protein kinase C (PKC) in regulation of glu-
cose uptake by metformin in skeletal muscle
cells. J Biol Chem 287(24):20088–20099.
https://doi.org/10.1074/jbc.M111.330746 - Woods A, Azzout-Marniche D, Foretz M,
Stein SC, Lemarchand P, Ferre P, Foufelle F,
Carling D (2000) Characterization of the role
of AMP-activated protein kinase in the regula-
tion of glucose-activated gene expression using
constitutively active and dominant negative
forms of the kinase. Mol Cell Biol 20
(18):6704–6711 - Corton JM, Gillespie JG, Hawley SA, Hardie
DG (1995) 5-Aminoimidazole-4-carboxamide
ribonucleoside. A specific method for activat-
ing AMP-activated protein kinase in intact
cells? Eur J Biochem 229(2):558–565 - Cool B, Zinker B, Chiou W, Kifle L, Cao N,
Perham M, Dickinson R, Adler A, Gagne G,
Iyengar R, Zhao G, Marsh K, Kym P, Jung P,
Camp HS, Frevert E (2006) Identification and
characterization of a small molecule AMPK
activator that treats key components of type
2 diabetes and the metabolic syndrome. Cell
Metab 3(6):403–416. https://doi.org/10.
1016/j.cmet.2006.05.005
304 Claudia Marinangeli et al.