Front Matter

173

Pesticide

Allethrin, d‐trans Estrogen Unknown

Amitrol Thyroid Thyroid peroxidase

inhibitors; inhibits thyroid

hormone synthesis.

Atrazine Neuroendocrine‐

pituitary (depression of

LH surge), testosterone

metabolism

Inhibits ligand binding to

androgen and estrogen

receptors

Carbaryl Estrogen and

progesterone

Unknown

Chlofentezine Thyroid Enhances secretion of thyroid

hormone

Chlordane Testosterone and

progesterone

Unknown

Cypermethrin Disruption of

reproductive function

Unknown

DDT Estrogen DDT and related compounds

act in a number of ways to

disrupt endocrine function by

binding with the estrogen

receptor, including estrogen

mimickry and antagonism,

altering the pattern of

synthesis or metabolism of

hormones, and modifying

hormone receptor levels

DDT metabolite,

p,p′‐DDE

Androgen Inhibits androgen binding to

the androgen receptor,

androgen‐induced

transcriptional activity, and

androgen action in

developing, pubertal and

adult male rats

Dicofol (Kelthane) Estrogen Unknown

Dieldrin Estrogen Binds to estrogen receptor;

competes with estradiol

Endosulfan Estrogen Unknown

Ethylene thiourea Thyroid Thyroid peroxidase inhibitor

Fenarimol Estrogen Estrogen receptor agonist

(Continued)

Compound(s) Hormone Mechanism

Table 7.1 (Continued)

Autism and Exposure to Environmental Chemicals