Front Matter

Tr act

Thalamus Amygdala

Hippocampus

Raphe nucleus

Locus ceruleus

Pituitary gland

Hypothalamus

Olfactory bulb

Odor/smell

stimulation

signaling

Olfactory
epithelium

Figure 3.1 Neural pathways of olfaction. Source: https://www.google.com/search?
newwindow=1&hl=en&site=imghp&tbm=isch&source=hp&biw=1264&bih=576&q=
OLFACTORY‐Sketch&oq=OLFACTORY‐Sketch&gs_l=img.3...1518.3940.0.5304.3.3.0.0.0.0.45.
87.2.2.0....0...1.1.64.img..1.0.0.0.kQrt2CdsE_4#imgrc=uyYvJhZrR‐7EhM. Adapted from
diy‐stress‐relief.com.

Oxytocin receptor developmental expression

First appearance ofOXR in the brain

Embryonic

day 14

Embryonic

day 18

Prenatal day 10

Prenatal day 13

Infant pattern

Caudate nucleus

Nucleus accumens Bed nucleus of thestria terminalis

Hypothalamus ventro-

medial nucleus

PN-Postnatal

Periform

cortex Lateral septum

Gestational

week 5

Gestational

week 8 Prenatal day 10Prenatal day 13

Amygdala

Anterior

Transient OXR expression

Dorsal

Olfactory

Adult pattern

Prenatal

Age day 19

Progressive appearance of OXRin discrete brain regime First transition to theadult pattern Second transition tothe adult pattern

Permanent OXR expression

(a)

(b)

Figure 4.1 Developmental trajectories of oxytocin receptor in the rat brain. (a) Schematic
time course of oxytocin receptor expression in the developing brain. (b) Oxytocin receptor
expression in the infant brain around prenatal period P10–P13. Regions in which a transient
oxytocin receptor expression is observed are colored in red. Regions in which oxytocin
receptor expression is maintained to adult life are colored in blue. OXR, oxytocin receptor.
Source: Ref. [10]. Copyright (c) 2015 Grinevich et al.