Front Matter

(Rick Simeone) #1

  • 1 Introduction to Autism Spectrum Disorders Prologue xiii

  • Smell of Autism

  • The Roundup™ Conundrum

  • Testosterone and Male Gender Bias

  • Connecting the Dots

  • Why Is There a “Spectrum” in Autism?

  • Are Genetic Mutations the Cause of Autism?

    • De Novo Mutation ASD Parent and Affected Child Exome Sequencing Display



  • More Than 1,000 Genetic and Genomic Disorders and Still Counting

    • Certain Brain Compartments? Why Do Certain Chemicals Induce Specific Depletions of 



  • Genesis of an ASD Brain

  • Pinpointing Critical Steps Where the Autistic Brain Emerges

  • Is Finding Mutations the Path to Discovering the Genesis of ASD?

  • Does Brain Size Matter?

  • How Autism Develops in a Fetal Brain

  • Why Is There a “Spectrum” in ASD?

  • ASD and Vaccines

  • Thimerosal Containing Mercury Stays in the Body and Is Very Toxic

  • Summary

  • References

  • 2 What is Autism?

  • Legacy of Autism

  • A Short History of Autism

  • DSM‐5 and the ASD Spectrum

  • Changes in ASD diagnosis approved by the APA vi Contents

    • Support Practices The impact of the Recent DSM‐5 Changes on Diagnosis and 



  • A New ASD Diagnosis Category: Social Communication Disorder

  • ASD or a Giant Spectrum of Socioneuropsychological Disorders

  • Asperger Syndrome

  • Pervasive Developmental Disorder Not Otherwise Specified

  • Autistic Disorder

  • Rett Syndrome

  • Childhood Disintegrative Disorder

  • Is Autism a Genetic Disease?

  • Synthetic Chemicals Lack Coevolutionary Adaptation

  • Myth of the Genetic Origin of Autism

  • Phenotypic Heterogeneity in Autism

    • Be Included in ASD Why Fragile X Syndrome or Tuberous Sclerosis Should Not



  • Tuberous Sclerosis

  • Is Finding Mutation the Path to Discovering the Origin of ASD?

  • How Quickly Does Human DNA Mutate?

  • What is the Mutation Rate in the Whole Human Genome?

  • Does Brain Size Matter?

  • Genetics versus Environment

  • References

  • 3 Olfaction and Autism

  • How Do We Smell?

  • Summary and Conclusions

  • References

  • 4 Oxytocin, Arginine Vasopressin and Autism Spectrum Disorder

  • Oxytocin

  • Why Oxytocin Therapy May be Important for ASD?

    • Oxytocin in ASD Hormones, Neuropeptide Arginine Vasopressin and 

    • Animals and in Man Development of Oxytocin and AVP Neurons in Various



  • Oxytocin and Social Experience in Development

  • Oxytocin and Developmental Neurological Disorders

  • Exogenous Oxytocin Treatments in Humans

  • Intranasal and Intravenous Oxytocin Studies in ASD

  • Oxytocin Trials in ASD: Beyond the Hype and Hope

  • Summary and Conclusions

  • References

  • 7 Autism and Exposure to Environmental Chemicals

  • Contribution of Fragrances to ASD

  • Effects of Fragrances on Male Oxytocin‐Receptor Positive Neurons

    • Neurons Effects of Fragrances on Female Oxytocin‐Receptor Positive

    • Development How Synthetic Chemicals in Fragrances Affect Fetal Brain



  • Synthetic Musks

  • How Do Synthetic Musks Get Into the Food Chain?

  • How Are People Exposed to Synthetic Musks?

  • Musks in Food

  • Diethyl Phthalate

  • Octinoxate

  • Benzyl Benzoate and Benzyl Salicylate

  • d‐Limonene

  • α‐Pinene

  • Synthetic EDCs

    • on Our Next Generations? Why Is It Important To Look at EDCs and Their Potential Effects



  • Where in Fetal Life Are Androgen Receptors Expressed?

  • Why Testosterone is Essential for Engineering a Male Brain

  • Spatial Memory

  • Anxiety‐Related Behavior

  • Play Fighting and Aggression

  • Adverse Effects of EDCs and Their Mechanisms of Action

  • Effects of Testosterone or AR Mimicking EDCs

  • Early Puberty in Males

  • Change in Sex Ratio

  • Effects of EDCs on Neurodevelopmental and Neuroendocrine Systems

  • EDC Effects on Steroid Hormone Receptors in the Brain

    • Human Race? Are the EDCs and other Synthetic Chemicals Depopulating the 



  • Summary

  • References

  • 8 Maternal Antibodies to Fetal Brain Neurons and Autism

    • A Double Jeopardy Link between Damage to the Fetal Brain and Maternal Antibodies:



  • Are there Examples of Such an Immune Mechanism?

  • Rh Incompatibility

  • ABO Incompatibility

    • Immune System? Why are Fetal Neuroantigens Immunogenic to the Maternal

    • Neurotoxicity, and Autoimmunity? Is There Any Evidence of a Link Between Synthetic Chemicals Exposure,



  • The Relationship between Autoimmunity and ASD Contents ix

  • The Detection of Fetal Brain Neuroantigens in the Maternal Blood

    • the Maternal Antibodies? What are the Functions of the Neuroantigens that are Being Destroyed by



  • Animal Models and Neuroantibodies to Autism

  • Rhesus Macaques Model

  • Studies Using Rodent Models

  • Why Do Some Autistic Children Have Bigger Brains?

    • of Neurodevelopmental or Neurodegenerative Disorders? Is There a Link between Autoimmunity and Other Forms



  • A Chicken and Egg Conundrum

    • Disorder Tourette Syndrome and Obsessive Compulsive



  • Other Contributing Factors in Neuropsychiatric Disorders

  • Infectious Flu Virus

  • Influenza Vaccine and Narcolepsy

  • Other Viral and Nonviral Infections

  • Blood–Brain Barrier

  • What is the BBB?

  • Summary and Conclusions

  • References

  • 9 Vaccines and Autism

  • Childhood Vaccines and Regressive Autism

  • Politics Versus Science in the Vaccination Era

    • Using Vaccines A Short Glimpse of the History of Vaccines: Justification for 



  • What is in the Vaccines?

  • Thimerosal

    • Pose a Higher Risk of Regressive Autism? What is the Evidence That Organomercurial Vaccines

    • A Scientific Narrative Why Thimerosal‐Containing Vaccines are Harmful:

    • Age of 3 years? How Much Mercury is Given to Children Before the 

    • After Vaccination? Why Do Only Small Numbers of Children Develop Regressive Autism

    • Who Are at Increased Risk for Regressive ASD? Can Measurements of Abnormal Cytokines Identify Children



  • Summary of Contributing Immunological Factors to ASD

  • References

  • Epilogue

  • Index

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