Devita, Hellman, and Rosenberg's Cancer

LWBK1006-01 LWW-Govindan-Review November 24, 2011 11:17

Chapter 1•Molecular Biology of Cancer Part 1 5

Question 1.22. Overexpression of Aurora B kinase could lead to all of the following,

EXCEPT:

A. Inability for sister chromatids to separate before anaphase

B. Rapid cell division

C. Aneuploidy

D. Increased disassembly of kinetochore proteins

Question 1.23. Which of the following characterizes cytogenetic abnormalities in most

human cancers?

A. Universal (monoclonal) population of cells containing identical cyto-

genetic abnormalities

B. Completely normal karyotype

C. Heterogenous complex karyotypes

D. Complete loss of X or Y chromosomes

Question 1.24. The “Hayflick phenomenon,” which is the name given to the limited

replicative potential of cells, is thought to arise from which of the follow-

ing?

A. The sequential loss of genetic material from the ends of chromosomes

(telomeres) with each round of division

B. The gradual accumulation of uncorrected genetic defects passed on

during division leading to senescence or malignancy

C. The activation of telomerase in aging cells leading to enzymatic loss

of genetic material from telomeres

D. Dividing eukaryotic cells outgrowing their vascular supply

Question 1.25. Which of the following statements is NOT accurate regarding telomerase?

A. It has both an RNA and a protein component.

B. It is a DNA polymerase.

C. Overexpression of telomerase is found in all cancer specimens.

D. Telomerase protects the integrity of the chromosomal ends.

Question 1.26. Senescence can be induced by all of the following, EXCEPT:

A. Telomere shortening

B. Prolonged DNA damage

C. High-density growth

D. Oncogene activation