Devita, Hellman, and Rosenberg's Cancer

LWBK1006-21 LWW-Govindan-Review December 12, 2011 19:6

Chapter 21•Genitourinary Cancer 287

Question 21.31. Which of the following statements about the androgen receptor is MOST

correct?

A. The majority of its activity in prostate cancer is due to its cytoplasmic

effects.

B. Upregulation of androgen receptor expression has been linked to

prostate cancer development.

C. Castration leads to complete inactivation of all androgen receptor-

mediated pathways.

D. Castrate-resistant prostate cancer is associated with upregulation of

androgen receptor expression.

Question 21.32. A 63-year-old uncircumcised man without any significant medical history

presents to his physician with an inability to retract the foreskin. Exam-

ination reveals phimosis, with an underlying painless ulcerated mass of

1 ×2 cm. A 2.5-cm hard node is palpated in the left inguinal region.

Biopsy of the penile lesion reveals squamous cell cancer. In addition to

wide surgical resection of the primary lesion, other appropriate therapeu-

tic and/or diagnostic maneuvers at this time include:

A. Four-week course of a broad-spectrum antibiotic

B. Left inguinal lymph node dissection

C. Bilateral inguinal radiotherapy

D. Taxane-based chemotherapy