Devita, Hellman, and Rosenberg's Cancer

LWBK1006-24 LWW-Govindan-Review December 12, 2011 19:15

CHAPTER 24 CANCER OF

THE BREAST

KATHY D. MILLER

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 24.1. What percentage of breast cancers is caused by germ line mutations?

A. 5%

B. 10%

C. 15%

D. 2%

Question 24.2. Which of the following about PARP1 is TRUE?

A. PARP 1 is a cellular enzyme involved in the base excision repair.

B. Tumors arising in patients with BRCA1, but not BRCA 2, mutations

may be sensitive to PARP inhibitors.

C. A and B.

D. None of the above.

Question 24.3. Characteristic features ofBRCA1-associated breast cancers include the

following except:

A. Aggressive features

B. Estrogen receptor (ER) positive

C. HER 2 negative

D. Young age at presentation

Question 24.4. Which of the following statements about HER2 is FALSE?

A. Lapatinib is a pure HER inhibitor.

B. The addition of trastuzumab to chemotherapy in the adjuvant setting

reduces the rate of recurrence by over 50%.

C. HER2 signaling is effected through homodimer formation.

D. A and C.

Corresponding chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 105 (Molecular Biology of

Breast Cancer), 106 (Malignant Tumors of the Breast).

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