Devita, Hellman, and Rosenberg's Cancer

LWBK1006-25 LWW-Govindan-Review December 12, 2011 19:21

352 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 25.11. Which of the following is TRUE regarding medullary thyroid carcinoma

(MTC)?

A. Genetic testing is not indicated in the absence of family history of

MTC.

B. Plasma metanephrines should be obtained within a few weeks after

thyroidectomy.

C. It is associated with radiation exposure.

D. It arises from the parafollicular C cells in the thyroid gland.

Question 25.12. A 67-year-old man presents with a rapidly growing mass on the anterior

part of the neck that is associated with progressive hoarseness. He also

reports a 12-lb weight loss. The remainder of his history is significant

for hypertension. Physical examination reveals mild respiratory distress,

a 6-cm mass on the anterior part of the neck, and adequate air entry. Core

needle biopsy confirms anaplastic thyroid carcinoma. CT scan shows a

thyroid mass with local invasion and multiple bilateral lung nodules. Lab-

oratory test results are normal. What is the most appropriate management

now?

A. Surgical debulking followed by adjuvant radioiodine

B. Radioactive iodine alone

C. Concurrent chemoradiation

D. Doxorubicin-based chemotherapy

Question 25.13. Which one of the following should be considered in the staging of

MTC?

A. Complete contrast-enhanced CT scan

B. Serum CEA and calcitonin

C. Bone survey

D. Octreoscan

E. All of the above

Question 25.14. All of the following are true regarding Hurthle cell carcinoma, EXCEPT:

A. It is a papillary carcinoma variant.

B. It is also known as Oxyphil cell carcinoma.

C. It has a worse prognosis than papillary or follicular carcinoma.

D. It is less iodine-avid than papillary or follicular carcinoma.

Question 25.15. Which of the following is TRUE about anaplastic thyroid carcinoma?

A. 6% of all thyroid cancers

B. Always stage IV

C. Slow growing and can be curable

D. Treated mainly with radioactive iodine