LWBK1006-25 LWW-Govindan-Review December 12, 2011 19:21
Chapter 25•Cancer of the Endocrine System 355Question 25.26. RET proto-oncogene mutation is associated with which of the following
condition(s)?
A. MEN2
B. Hirschsprung disease
C. MTC
D. A and BQuestion 25.27. A 48-year-old woman presents with amenorrhea for the past 5 months.
She also reports appearance of facial hair, development of new acne
lesions on the face, and recent unexplained weight gain. Medical his-
tory is unremarkable. On physical examination, blood pressure is
130/82 mm Hg, weight is 195 lbs, thick facial hair, and multiple acne-
like lesions on the face are noted, and the remainder of the examination is
normal. CT scan of the abdomen reveals a 6-cm mass in the left adrenal
gland without other identified lesions. What is the most appropriate plan
of management?
A. Percutaneous image-guided needle biopsy
B. Metabolic workup followed by surgical resection
C. Observation and reassurance that symptoms are related to meno-
pause
D. Metabolic workup followed by mitotaneQuestion 25.28. Recurrent metastatic pheochromocytoma can be treated by all of the fol-
lowing, EXCEPT:
A. Systemic chemotherapy combination chemotherapy cyclophospha-
mide, vincristine, and doxorubicin
B. High-dose meta-iodo-benzyl-guanidine therapy
C. External beam radiation
D. MitotaneQuestion 25.29. All of the following are true regarding carcinoid tumors, EXCEPT:
A. The most common site is the small bowel, followed by the rectum.
B. Diarrhea, flushing, and bronchospasm are classic features.
C. Complete surgical resection of all neoplastic tissue is the preferred
therapy.
D. Diarrhea can be controlled with long-acting octreotide.
E. External beam radiation is ineffective in treating this disease.Question 25.30. Adrenocortical carcinoma is favored over adenoma by which of the fol-
lowing CT scan features?
A. Size>6cm
B. Density of<10 Hounsfield units on nonenhanced CT
C. Washout of>50% at 15 minutes after contrast
D. Homogenous appearance