Devita, Hellman, and Rosenberg's Cancer

LWBK1006-26 LWW-Govindan-Review December 12, 2011 19:29

CHAPTER 26 SARCOMAS

DOUGLAS R. ADKINS•BRIAN A. VAN TINE•TONI B. RACHOCKI

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 26.1. Which of the following inherited syndromes represent a predisposing fac-

tor for the development of soft tissue sarcoma?

A. Retinoblastoma

B. Li-Fraumeni syndrome

C. Neurofibromatosis type I

D. All of the above

Question 26.2. Which of the following is NOT true about radiation-induced sarcomas?

A. Cancer history usually includes breast cancer, lymphoma, and cervical

cancer.

B. These sarcomas have a favorable prognosis.

C. Osteogenic sarcoma, malignant fibrous histiocytoma (MFH), angio-

sarcoma, and lymphangiosarcoma are the usual histologic subtypes.

D. They usually occur 10 to 30 years after radiation exposure.

Question 26.3. Which clonal cytogenetic abnormality is associated with the correct sar-

coma subtype?

A. Ewing’s sarcoma andt(11; 22) (q24; q12)

B. Synovial sarcoma andt(12; 16) (q13; p11)

C. Myxoid liposarcoma andt(x; 18) (p11; q11)

D. Alveolar rhabdomyosarcoma andt(17; 22) (q22; q13)

Question 26.4. A 20-year-old man presents with right knee pain. X-ray reveals a “sun-

burst” appearance in the distal femur. Biopsy reveals high-grade osteosar-

coma. No distant metastases are identified. Which of the following is the

most appropriate treatment?

A. Limb-sparing resection

B. Limb-sparing resection and adjuvant chemotherapy

C. Definitive radiation

D. Neoadjuvant chemotherapy, limb-sparing resection, and adjuvant

chemotherapy

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 114 (Molecular Biology of

Sarcomas), 115 (Soft Tissue Sarcoma), and 116 (Sarcomas of Bone).

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