Devita, Hellman, and Rosenberg's Cancer

LWBK1006-26 LWW-Govindan-Review December 12, 2011 19:29

368 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 26.15. Which of the following is TRUE about chemotherapy treatment of

metastatic soft tissue sarcoma?

A. Escalating doses of doxorubicin or ifosfamide do not improve tumor

response rates over standard doses of these agents.

B. Leiomyosarcoma is uniquely sensitive to ifosfamide, whereas synovial

cell sarcoma is not.

C. Paclitaxel shows broad-spectrum activity.

D. Dacarbazine has modest activity.

Question 26.16. A 30-year-old man presents with a permeative bone tumor in the distal

femur. Open biopsy reveals a MFH. Radiologic imaging does not find

distant metastases. What is the most appropriate treatment?

A. Limb-sparing resection with wide margins

B. Definitive radiation

C. Chemotherapy

D. Preoperative chemotherapy, limb-sparing resection, and adjuvant

chemotherapy

Question 26.17. Which of the following is NOT true regarding osteosarcoma?

A. Approximately 20% of patients with localized high-grade disease

treated with resection alone remain disease free 5 years later.

B. Approximately 60% to 80% of patients with localized high-grade

disease treated with resection and chemotherapy remain disease free

5 years later.

C. Parosteal (low-grade cortical) osteosarcoma is best treated with resec-

tion and chemotherapy.

D. Periosteal osteosarcoma is best treated with resection and chemother-

apy.

Question 26.18. A 45-year-old man presents with a left-sided pelvic pain. CT reveals a

5 cm mass with appearance of chondroid matrix, arising from the left

side of the pelvic girdle. Bone biopsy reveals chondrosarcoma. Which of

the following is NOT true regarding chondrosarcomas?

A. Most are low-grade tumors.

B. Most are treated with resection.

C. Children have a poorer prognosis than adults.

D. Adjuvant chemotherapy has no role in the management of non-

metastatic disease.

Question 26.19. A 22-year-old woman presents with a giant cell tumor (GCT) of the distal

femur. Appropriate treatment would be:

A. Curettage and debridement

B. Amputation

C. Radiation

D. Preoperative chemotherapy, resection, and adjuvant chemotherapy