Devita, Hellman, and Rosenberg's Cancer

LWBK1006-28 LWW-Govindan-Review December 9, 2011 16:52

386 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 28.15. A 62-year-old man presents with nausea, vomiting, and severe headache.

MRI scan of the brain reveals a 5-cm mass in the posterior fossa. The

patient undergoes surgical resection of the mass, and pathology is reported

as ependymoma. Further treatment should include:

A. Radiation therapy

B. Concurrent chemoradiation with temozolomide

C. Check MGMT methylation status

D. Chemotherapy alone with cisplatin plus etoposide

Question 28.16. A 53-year-old woman presents with mental status changes; brain MRI

identifies a left frontal tumor with dural marginal thickening. She under-

goes a resection of the tumor and the involved dural attachments. The

histopathology is meningioma, WHO grade I. Further treatment should

include:

A. Watchful waiting

B. Adjuvant radiation therapy

C. Chemotherapy

D. Radiosurgery

Question 28.17. In immunocompetent patients with primary CNS lymphoma, with good

performance status and adequate renal function, appropriate first-line

therapy comprises of:

A. High-dose methotrexate

B. R-CHOP

C. Whole brain radiation

D. None of the above

Question 28.18. Long-term follow-up data showed improved survival for patients with

GBM, receiving brain radiation with temozolomide compared to radia-

tion alone, with the exception of patients with:

A. Age>50 years

B. Unmethylated MGMT

C. EGFR mutation positive

D. None of the above

Question 28.19. Which of the following is LEAST commonly associated with cranio-

pharyngioma?

A. Sexual dysfunction

B. Visual dysfunction

C. Hypothyroidism

D. Diabetes insipidus