Devita, Hellman, and Rosenberg's Cancer

LWBK1006-29 LWW-Govindan-Review December 9, 2011 15:36

400 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 29.36. All of the following statements about treatment of RMS are true,

EXCEPT:

A. Treatment of parameningeal RMS with intracranial extension should

include radiation.

B. Local radiation should be used for all patients with microscopic or

gross residual RMS.

C. Hyperfractionated radiotherapy is better than conventional fraction-

ated radiation for control of local, regional, or metastatic RMS.

D. Surgical intervention in RMS should aim for complete tumor resec-

tion with negative margins whenever possible.

Question 29.37. Small round blue cell tumors of childhood include all of the following,

EXCEPT:

A. Ewing sarcoma

B. Neuroblastoma

C. RMS

D. Wilms’ tumor

Question 29.38. The most frequent site of metastasis in Ewing sarcoma is:

A. Liver

B. Lung

C. Spleen

D. Lymph nodes

Question 29.39. The most important feature that distinguishes osteosarcoma from Ewing

sarcoma, chondrosarcoma, and fibrosarcoma is:

A. Metaphyseal rather than diaphyseal origin

B. The production of osteoid

C. A “sunburst” pattern on radiologic examination

D. Specificity of chromosomal translocations by karyotyping

Question 29.40. All of the following treatment modalities are useful in osteosarcoma,

EXCEPT:

A. Isolated surgery in low-grade tumors

B. Chemotherapy regimen that includes cisplatin, doxorubicin, and

methotrexate

C. Ifosfamide combined with biologic response modifier liposomal

muramyl tripeptide phosphatidylethanolamine (MTP-PE)

D. Radiation therapy

Question 29.41. All of the following are good prognostic factors in the outcome of Ewing

sarcoma, EXCEPT:

A. Localized tumor<8 cm in diameter and volume<100 mL

B. Primary pelvic tumors

C. Low serum lactate dehydrogenase level

D. Type 1 EWS-FLI1 fusion transcripts