Devita, Hellman, and Rosenberg's Cancer

LWBK1006-35 LWW-Govindan-Review November 24, 2011 11:26

CHAPTER 35 CANCER OF

UNKNOWN PRIMARY SITE

MUHAMMAD ATIF WAQAR

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 35.1. In patients with cancer of unknown primary, what is the most common

histology seen on initial light microscopic exam?

A. Adenocarcinoma

B. Poorly differentiated carcinoma

C. Squamous cell carcinoma

D. Neuroendocrine carcinoma

Question 35.2. Which of the following statements is CORRECT regarding aggressive

neuroendocrine carcinomas of unknown primary site?

A. Patients with thyroid transcription factor-1 (TTF-1) positive tumors

should undergo bronchoscopy.

B. They rarely secrete bioactive substances.

C. Colonoscopy should be considered in patients whose tumors stain

positive for CDX2.

D. All of the above.

Question 35.3. Which of the following immunohistochemical (IHC) stains is the most

specific in guiding the diagnostic workup for carcinoma of unknown pri-

mary?

A. Common leukocyte antigen

B. TTF-1

C. Chromogranin

D. Cytokeratin 7 (CK-7)

Corresponding Chapter inCancer: Principles & Practice of Oncology,Ninth Edition: 137 (Cancer of Unknown

Primary Site).

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