Devita, Hellman, and Rosenberg's Cancer

LWBK1006-35 LWW-Govindan-Review November 24, 2011 11:26

478 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 35.12. Immunoperoxidase staining patterns may be helpful in the differential

diagnosis of poorly differentiated neoplasms. Which of the following

tumor types is INCORRECTLY matched with the characteristic findings

on immunoperoxidase staining?

A. TTF-1 (+), Surf-A, and Surf-B (+); small cell carcinoma

B. CK 7 (+), CK20 (–), gross cystic fluid protein 15 (+), ER (+); breast

carcinoma

C. CK7 (–), CK20 (+); colorectal carcinoma

D. CK7 (+), CA19-9 (+); pancreas carcinoma

Question 35.13. The identification of characteristic cytogenetic abnormalities can help

identify the site of origin of a tumor in some cases. Which of the fol-

lowing tumor types is INCORRECTLY matched with the characteristic

cytogenetic abnormality?

A. Deletion of 1p; neuroblastoma

B. Deletion of 11p; alveolar rhabdomyosarcoma

C. Isochromosome of 12p; germ cell tumors

D. Deletion of 3p; small cell carcinoma

Question 35.14. A 35-year-old man presents with a 3-month history of an enlarging lump

in the right inguinal region. He has a 3 cm right inguinal lymph node

palpable on exam. Genital exam, digital rectal exam, and anoscopy are

normal. Core biopsy of the mass reveals poorly differentiated squamous

carcinoma. CT of the abdomen and pelvis and chest X-ray are negative

for any other sites of involvement. Which of the following is the most

appropriate treatment for him?

A. Palliative chemotherapy

B. Definitive radiation therapy

C. Referral to hospice

D. Surgical consultation, radiation oncology consultation, chemo-

therapy