Devita, Hellman, and Rosenberg's Cancer

LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19

CHAPTER 3 ETIOLOGY OF

CANCER PART 1

SHIRISH M. GADGEEL

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 3.1. All the following statements regarding the relationship between cigarette

smoking and lung cancer are correct, EXCEPT:

A. The duration of smoking is the strongest determinant of lung cancer

in smokers.

B. Smoking increases the risk of all histologic types of lung cancer.

C. The risk of developing lung cancer in ex-smokers drops to the level

of never smokers two years after smoking cessation.

D. The risk of developing lung cancer increases with the number of

cigarettes smoked.

Question 3.2. The role of specific tobacco product carcinogens in specific tumors is

characterized by the following, EXCEPT:

A. Polycyclic aromatic hydrocarbons are major causative factors in lung

cancer.

B. Aromatic amines are a major cause of bladder cancer.

C. N-nitrosamines are important causative factors in esophageal

cancer.

D. Nicotine is an important carcinogen in the causation of laryngeal

cancer.

Question 3.3. The following enzymes are involved in metabolic activation of the

carcinogens in cigarette smoke:

A. P450 enzyme 1A1 and 1A2

B. Glutathione-S-transferases and uridine diphosphate-glucuronosyl

transferases

C. Nucleotide excision repair enzymes

D. None of the above

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 13 (Tobacco), 14 (Cancer

Susceptibility Syndromes), 15 (DNA Viruses), 16 (RNA Viruses), and 17 (Inflammation).

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