Devita, Hellman, and Rosenberg's Cancer

LWBK1006-39 LWW-Govindan-Review December 12, 2011 20:30

504 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 39.4. Which among the following is the earliest fundoscopic sign for increased

intracranial pressure?

A. Absence of venous pulsations within the center of the optic disk

B. Blurring of the disk margins

C. Disk hemorrhage

D. Foster-Kennedy syndrome

Question 39.5. A 57-year-old man presents with severe back pain and bilateral leg weak-

ness for 3 days. Magnetic resonance imaging (MRI) of the spine reveals

metastatic lesion at T10 vertebral body with significant cord compression.

What are the most likely primary tumors?

A. Lung cancer and breast cancer

B. Lung cancer and lymphoma

C. Breast cancer and lymphoma

D. Colon cancer and prostate cancer

Question 39.6. Which of the following signs indicate damage to pontine structures?

A. Midsize pupils unresponsive to light

B. Coma

C. Absence of oculocephalic reflex

D. Ataxic breathing

Question 39.7. Which of the following statements regarding rasburicase is FALSE?

A. Mechanism of action is inhibition of urate oxidase

B. Should be avoided in patients with glucose 6-phosphate deficiency

(G6PD)

C. Antibodies against rasburicase or its epitopes may occur in up to 20%

of cases

D. None of the above; all answers are correct

Question 39.8. A 28-year-old man presents with newly diagnosed acute myeloid

leukemia. He has a white cell count of 140,000/mm^3 , glucose of

96 mg/dL, sodium of 138 mEq/L, potassium of 4 mEq/L, creatinine

of 1.1 mg/dL, blood urea nitrogen (BUN) of 15 mg/dL, uric acid of

4.8 mg/dL, albumin of 5.2 g/dL, and calcium of 10.2 mg/dL. He is started

on induction chemotherapy, aggressive intravenous fluids and allopurinol.

Twelve hours later, the patient developed cardiac arrest not responsive to

cardiopulmonary resuscitation and died. What is the most likely cause of

his death?

A. Leukostasis

B. Electrolyte imbalance

C. Pulmonary embolism

D. Chemotherapy-induced cardiac arrhythmia