Devita, Hellman, and Rosenberg's Cancer

LWBK1006-41 LWW-Govindan-Review November 24, 2011 11:29

520 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 41.18. Acquired von Willebrand’s disease is seen in all the following, EXCEPT:

A. Plasma cell dyscrasias

B. Lymphoma

C. Gastric cancer

D. Hepatocellular carcinoma

Question 41.19. Cancer-related thrombosis results from which of the following mecha-

nisms?

A. Direct generation of thrombin

B. Increased platelet aggregation

C. Decreased levels of protein C, protein S, and antithrombin

D. All of the above

Question 41.20. A 39-year-old woman presents with ptosis, diplopia, and proximal muscle

weakness, which improve with rest. Tensilon challenge test is positive,

with improvement in weakness following edrophonium administration.

Which of the following diagnostic tests is indicated?

A. Computed tomography (CT) scan of the chest

B. Nerve conduction studies

C. Serum calcium level

D. Muscle biopsy

Question 41.21. Which of the following about limbic encephalitis (LE) is INCORRECT?

A. Testicular cancers associated with LE have the anti-Hu antibody.

B. It may be mistaken for herpes simplex encephalitis.

C. Most cases are associated with SCLC.

D. It is one of the more treatable forms of central nervous system (CNS)

paraneoplastic disorders.

Question 41.22. The anti-Yo antibody CNS paraneoplastic disorder has all these in com-

mon, EXCEPT:

A. It is commonly associated with ovarian and breast cancer.

B. The antibody is active against the Purkinje cells.

C. It causes opsoclonus-myoclonus.

D. The disorder is subacute in onset and usually progressive.

Question 41.23. Which of the following about LES is INCORRECT?

A. Sixty percent of patients with LES have an underlying cancer.

B. The malignancy most associated with LES is SCLC.

C. It is a pure motor syndrome.

D. Proximal weakness is the common presenting symptom.

Question 41.24. Melanoma-associated retinopathy includes all the following, EXCEPT:

A. It most commonly appears at the metastatic stage.

B. It is more common in men.

C. Only cones are affected, sparing rods.

D. Progressive blindness is unusual.