Devita, Hellman, and Rosenberg's Cancer

LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19

38 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 3.25. Pathogenesis of increased risk of cancer in HIV-infected patients is char-

acterized by the following:

A. HIV infection leads to the insertion of the viral genome at critical

locations of the cellular genome leading to chimeric proteins that are

procarcinogenic.

B. HIV genome contains oncogenes that are transcribed in the infected

cells causing cancers.

C. HIV infection causes immune deficiency in infected patients, which

contributes to the development of cancer.

D. HIV reverse transcriptase activates many cellular oncogenes during

viral replication.

Question 3.26. Acquired immune deficiency syndrome (AIDS)-related Kaposi’s sarcoma

(KS) is characterized by the following, EXCEPT:

A. Immune deficiency caused by HIV is involved in the pathogenesis of

KS.

B. HHV-8 infection in HIV-infected patients is the etiologic agent of KS.

C. Tat protein secreted by the infected HIV cells increases the level of

various cytokines and contributes to the pathogenesis of KS.

D. Mutation induced by HIV in infected endothelial cells contributes to

the pathogenesis of KS.

Question 3.27. Pathogenesis of lymphomas in patients with HIV is linked to all the fol-

lowing, EXCEPT:

A. Epstein–Barr virus (EBV) in patients with HIV

B. Immune deficiency caused by HIV

C. Lymphomas that arise in the HIV-infected CD4+T cells

D. HIV-induced cytokine dysregulation

Question 3.28. Hepatitis C virus (HCV) is:

A. An RNA virus that is transmitted by percutaneous routes

B. A retrovirus that is transmitted by percutaneous route

C. A DNA virus that is transmitted by the fecal–oral route

D. None of the above

Question 3.29. Which of the following statements is correct regarding the association

between HCV infection and hepatocellular carcinoma (HCC)?

A. Approximately 1% to 5% of patients with chronic HCV infection

will develop HCC.

B. The incidence of HCC has decreased during the last few decades, due

to better screening of blood products for HCV.

C. Vaccination against HCC is an effective means for preventing HCC.

D. All of the above.