Devita, Hellman, and Rosenberg's Cancer

LWBK1006-04 LWW-Govindan-Review November 24, 2011 11:19

CHAPTER 4 ETIOLOGY OF

CANCER PART 2

NIKHIL I. KHUSHALANI•KAUNTEYA REDDY

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 4.1. Cancer in humans is:

A. A genetically determined sequela of aging

B. A manifestation of individual exposure to carcinogens

C. A combination of a genetically susceptible individual and exposure

to carcinogen

D. An unknown mechanism of development

Question 4.2. Which of the following has been implicated in increased cancer risk?

A. Tobacco and alcohol

B. Diet

C. Sexual behavior

D. All of the above

Question 4.3. Match the following agents most commonly involved with cancer of that

particular organ:

A. Lung 1. Asbestos

B. Pleura 2. Benzene

C. Urinary bladder 3. Tobacco

D. Liver 4. Cadmium

E. Bone marrow 5. Ultraviolet (UV) light

F. Prostrate 6. Phenacetin

G. Skin 7. Aflatoxin

Question 4.4. Which of the following statements is TRUE?

A. Interaction of genotoxic carcinogens is random.

B. Interaction of genotoxic carcinogens is selective based on their class.

C. Genotoxic carcinogens can cause base mispairing and small deletions,

but not large deletions.

D. All toxins implicated in cancers are genotoxic.

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 18 (Chemical Factors),

19 (Physical Factors), 20 (Dietary Factors), and 21 (Obesity and Physical Activity).

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