154 Notes
- Neoadjuvant CRT (CROSS regimen):
RT dose fractionation: 41.4 Gy in 23 fractions of 1.8 Gy, five
fractions per week.
Chemotherapy: weekly paclitaxel (50 mg/m^2 ) and carboplatin
(AUC = 2) concurrent with RT.
The whole course of RT lasted for 5 weeks with total five cycles
of weekly chemotherapy.
Alternative regime: cisplatin (100 mg/m^2 ) day 1 and 5FU
(1000 mg/m^2 /day) for 4 days on week 1 and 5 concur-
rent RT (50.4 Gy/28 fractions over 5.6 weeks). - Definitive CRT (RTOG 8501):
RT dose fractionation: 50 Gy in 25 fractions over 5 weeks.
Chemotherapy: cisplatin 75 mg/m^2 and 5FU 1000 mg/m^2 /
day continuous infusion for 4 days, two cycles concurrent
with RT and two additional cycles after completing RT.
Fig. 3 Dose volume histogram showing the volume of different structures irradiated to different doses (Y-axis
is volume of structure and X-axis is the dose received). The dose statistics table below shows the summarized
doses for planning target volume (PTV-41.4 Gy/23 fr in red line), organs at risks including liver (light brown
line), heart (brown line), right lung (light green line), total lung (green line), left lung (dark green line), and spinal
cord (light blue line)
Radiotherapy