The AHA Guidelines and Scientifi c Statements Handbook
Classic claudication symptoms:
Muscle fatigue, cramping, or pain that reproducibly begins during exercise and
that promptly resolves with restChart document the history of walking impairment (pain-free and total walking
distance) and specific lifestyle limitationsDocument pulse examinationABI less than or equal to 0.90Confirmed PAD diagnosisGo to Figure 9.5, Treatment of ClaudicationRisk factor normalization:
Immediate smoking cessation
Treat hypertension: JNC-7 guidelines
Treat lipids: NCEP ATP III guidelines
Treat diabetes mellitus: HbAlc less than 7%*Pharmacological risk reduction:
Antiplatelet therapy
(ACE inhibition;† Class IIa)ABIExercise ABI
(TBI, segmental
pressure, or duplex
ultrasound
examination)No PAD or
consider arterial
entrapment
syndromesABI greater
than 0.90Abnormal
resultsNormal
resultsFig. 9.4 Diagnosis of claudication and systemic risk treatment.
- It is not yet proven that treatment of diabetes mellitus will signifi cantly reduce peripheral arterial disease (PAD)-specifi c (limb ischemic) endpoints. Primary
treatment of diabetes mellitus should be continued according to established guidelines.
† The benefi t of angiotensin-converting enzyme (ACE)-inhibition in individuals without claudication has not been specifi cally documented in prospective clinical
trials, but has been extrapolated from other “at risk” populations.
ABI, ankle-brachial index; HgbA1c, hemoglobin A; JNC-7, Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment
of High Blood Pressure; LOE, level of evidence; NCEP ATP-III, National Cholesterol Education Program Adult Treatment Panel III.
Exercise and lower extremity pad rehabilitation
See Table 9.7.
Class I
1 A program of supervised exercise training is rec-
ommended as an initial treatment modality for
patients with intermittent claudication. (Level of
Evidence: A)
2 Supervised exercise training should be performed
for a minimum of 30 to 45 minutes, in sessions
performed at least three times per week for a
minimum of 12 weeks. (Level of Evidence: A)Class IIb
The usefulness of unsupervised exercise programs is
not well established as an effective initial treatment
modality for patients with intermittent claudication.
(Level of Evidence: B)