Cannabinoids

Effects of Cannabinoids on Neurotransmission 335

Table 1.

(continued

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

Glutamate

Rat

Cerebellum(brain slice)

Electrophysiology (patch clamp) No details given

Kreitzer and Regehr 2001

Glutamate

Mouse

Cerebellum(brain slice)

Electrophysiology (patch clamp) No details given

Maejima et al. 2001

Glutamate

Mouse

Synaptosomesfrom whole brain

Endogenous glutamatechemically determined(veratridine-evoked release)

No CB

receptors are involved 1

Na

+

channels inhibited

Nicholson et al. 2003

Glutamate

Rat

Spinal cord(cord slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Morisset and Urban 2001

4-AP, 4-aminopyridine; cAMP, cyclic adenosine monophosphate; extracell., extrac

ellular; GABA,

γ-aminobutyric acid; PKA, protein kinase A.

aIn this exceptional study, cannabinoids did not decrease glutamate release, but

increased it.