Cannabinoids

340 B. Szabo and E. Schlicker

Table 2.

(continued

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

GABA

Rat

Cerebellum(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

IntracellularCa

2+

concentrationdecreased

Diana et al. 2002

GABA

Rat

Cerebellum(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Szabo et al. 2004

GABA

Mouse

Cerebellum(brain slice)

Electrophysiology (patch clamp) No details given

Yoshida et al. 2002

GABA

Mouse

Synaptosomesfrom whole brain

Endogenous GABA chemicallydetermined, Veratridine-induced release

No CB

receptors are involved 1

Na

+

channels inhibited

Nicholson et al. 2003

GABA, glycine

Rat

Superficialmedullarydorsal horn

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Jennings et al. 2001

GABA,

γ-aminobutyric acid.