Effects on the Immune System 423Titishov N, Mechoulam R, Zimmerman AM (1989) Stereospecific effects of (–)- and (+)-7-
hydroxy-delta-6-tetrahydrocannabinol-dimethylheptyl on the immune system of mice.
Pharmacology 39:337–349
Valk P, Verbakel S, Vankan Y, Hol S, Mancham S, Ploemacher R, Mayen A, Lowenberg B,
Delwel R (1997) Anandamide, a natural ligand for the peripheral cannabinoid receptor
is a novel synergistic growth factor for hematopoietic cells. Blood 90:1448–1457
Vethanayagam D, Pugsley S, Dunn EJ, Russell D, Kay JM, Allen C (2000) Exogenous lipid
pneumonia related to smoking weed oil following cadaveric renal transplantation. Can
Respir J 7:338–342
Waksman Y, Olson JM, Carlisle SJ, Cabral GA (1999) The central cannabinoid receptor (CB1)
mediates inhibition of nitric oxide production by rat microglial cells. J Pharmacol Exp
Ther 288:1357–1366
Wallace JM, Lim R, Browdy BL, Hopewell PC, Glassroth J, Rosen MJ, Reichman LB, Kvale
PA (1998) Risk factors and outcomes associated with identification of Aspergillus in
respiratory specimens from persons with HIV disease. Pulmonary Complications of
HIV Infection Study Group. Chest 114:131–137
Warner JF, Dennert G (1982) Effects of a cloned cell line with NK activity on bone marrow
transplants, tumour development and metastasis in vivo. Nature 300:31–34
Watzl B, Scuderi P, Watson RR (1991) Marijuana components stimulate human peripheral
blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha
in vitro. Int J Immunopharmacol 13:1091–1097
Whitfield RM, Bechtel LM, Starich GH (1997) The impact of ethanol and Marinol/marijuana
usage on HIV+/AIDS patients undergoing azidothymidine, azidothymidine/dideoxy-
cytidine, or dideoxyinosine therapy. Alcohol Clin Exp Res 21:122–127
WileyJL,MartinBR(2002)Cannabinoidpharmacology:implicationsforadditionalcannabi-
noid receptor subtypes. Chem Phys Lipids 121:57–63
Wiley JL, Martin BR (2003) Cannabinoid pharmacological properties common to other
centrally acting drugs. Eur J Pharmacol 471:185–193
WirguinI,MechoulamR,BreuerA,SchezenE,WeidenfeldJ,BrennerT(1994)Suppressionof
experimental autoimmune encephalomyelitis by cannabinoids. Immunopharmacology
28:209–214
Yebra M, Klein TW, Friedman H (1992) Delta-9-tetrahydrocannabinol suppresses con-
canavalin A induced increase in cytoplasmic free calcium in mouse thymocytes. Life Sci
51:151–160
Zheng ZM, Specter S, Friedman H (1992) Inhibition by delta-9-tetrahydrocannabinol of
tumor necrosis factor alpha production by mouse and human macrophages. Int J Im-
munopharmacol 14:1445–1452
Zhu LX, Sharma S, Stolina M, Gardner B, Roth MD, Tashkin DP, Dubinett SM (2000) Delta-
9-tetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated,
cytokine-dependent pathway. J Immunol 165:373–380
Zhu W, Igarashi T, Qi ZT, Newton C, Widen RE, Friedman H, Klein TW (1993) Delta-9-
tetrahydrocannabinol (THC) decreases the number of high and intermediate affinity IL-
2receptorsoftheIL-2dependentcelllineNKB61A2.IntJImmunopharmacol15:401–408
Zhu W, Newton C, Daaka Y, Friedman H, Klein TW (1994) Delta-9-tetrahydrocannabinol
enhances the secretion of interleukin 1 from endotoxin-stimulated macrophages. J Phar-
macol Exp Ther 270:1334–1339
Zhu W, Igarashi T, Friedman H, Klein TW (1995) Delta-9-tetrahydrocannabinol (THC)
causes the variable expression of IL2 receptor subunits. J Pharmacol Exp Ther 274:1001–
1007
Zhu W, Friedman H, Klein TW (1998) Delta-9-tetrahydrocannabinol induces apoptosis in
macrophages and lymphocytes: involvement of Bcl-2 and caspase-1. J Pharmacol Exp
Ther 286:1103–1109
Zimmerman S, Zimmerman AM, Cameron IL, Laurence HL (1977) Delta-1-tetrahydro-
cannabinol, cannabidiol and cannabinol effects on the immune response of mice. Phar-
macology 15:10–23