Cannabinoids

602 P. Pacher et al.

Fig. 1.

Hemodynamic effects of anandamide in anesthetized mice. Representa

tive recordings of the effects of anandamide [20 mg/kg i.v.,

N-arachidonoyl-ethanolamine (

AEA

)]

on mean arterial pressure (

MAP

,top panel

), cardiac contractility (left ventricular systolic pressure (

LVSP

)andd

P/d

t(

dPdt

);middle panel

) and pressure-volume relations (

bottom

panel

) in a pentobarbital-anesthetized C57BL6 mouse. The five parts of the

middle

and

bottom panels

represent baseline conditions (

Bl

), phase I (

I), phase II (

II), and phase III (

III

)

of the anandamide response, and recovery

10 min

following the injection. The

arrow

indicates the injection of the drug. The decrease of the amplitude of PV loops and shift

to

the right indicate decrease of cardiac contractile performance