Cannabinoid Tolerance and Dependence 717Whitlow CT, Freedland CS, Porrino LJ (2003) Functional consequences of the repeated
administration of delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend 71:169–
177
Wiesbeck GA, Schuckit MA, Kalmijn JA, Tipp JE, Bucholz KK, Smith TL (1996) An evaluation
of the history of a marijuana withdrawal syndrome in a large population. Addiction
91:1469–1478
Wikler A (1976) Aspects of tolerance to and dependence on cannabis. Ann N Y Acad Sci
282:126–147
Willoughby KA, Moore SF, Martin BR, Ellis EF (1997) The biodisposition and metabolism
of anandamide in mice. J Pharmacol Exp Ther 282:243–247
Wise RA (1996) Addictive drugs and brain stimulation reward. Annu Rev Neurosci 19:319–
340
Zhuang S, Kittler J, Grigorenko EV, Kirby MT, Sim LJ, Hampson RE, Childers SR, Deadwyler
SA (1998) Effects of long-term exposure to delta9-THC on expression of cannabinoid
receptor (CB1) mRNA in different rat brain regions. Brain Res Mol Brain Res 62:141–149
Zimmer A, Valjent E, Konig M, Zimmer AM, Robledo P, Hahn H, Valverde O, Maldon-
ado R (2001) Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-
deficient mice. J Neurosci 21:9499–9505