References 129110 Dingermann, T., Frank‐Stoll, U., Werner, H., Wissmann, A., Hillen, W.,
Jacquet, M., and Marschalek, R. (1992) RNA polymerase III catalysed
transcription can be regulated in Saccharomyces cerevisiae by the bacterial
tetracycline repressor‐operator system. EMBO J., 11 (4), 1487–1492.
111 Nagahashi, S., Nakayama, H., Hamada, K., Yang, H., Arisawa, M., and Kitada, K.
(1997) Regulation by tetracycline of gene expression in Saccharomyces
cerevisiae. Mol. Gen. Genet., 255 (4), 372–375.
112 Mnaimneh, S., Davierwala, A.P., Haynes, J., Moffat, J., Peng, W.T., Zhang, W.,
Yang, X., Pootoolal, J., Chua, G., Lopez, A., Trochesset, M., Morse, D., Krogan,
N.J., Hiley, S.L., Li, Z., Morris, Q., Grigull, J., Mitsakakis, N., Roberts, C.J.,
Greenblatt, J.F., Boone, C., Kaiser, C.A., Andrews, B.J., and Hughes, T.R. (2004)
Exploration of essential gene functions via titratable promoter alleles. Cell,
118 (1), 31–44.
113 Zhang, N., Osborn, M., Gitsham, P., Yen, K., Miller, J.R., and Oliver, S.G. (2003)
Using yeast to place human genes in functional categories. Gene, 303 , 121–129.
114 Bellí, G., Garí, E., Piedrafita, L., Aldea, M., and Herrero, E. (1998) An activator/
repressor dual system allows tight tetracycline‐regulated gene expression in
budding yeast. Nucleic Acids Res., 26 (4), 942–947.
115 Klug, A. (2010) The discovery of zinc fingers and their applications in gene
regulation and genome manipulation. Annu. Rev. Biochem., 79 (1), 213–231.
116 Garg, A., Lohmueller, J.J., Silver, P.A., and Armel, T.Z. (2012) Engineering
synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res.,
40 (15), 7584–7595.
117 Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E.,
Stern‐Ginossar, N., Brandman, O., Whitehead, E.H., Doudna, J.A., Lim, W.A.,
Weissman, J.S., and Qi, L.S. (2013) CRISPR‐mediated modular RNA‐guided
regulation of transcription in eukaryotes. Cell, 154 (2), 442–451.
118 Farzadfard, F., Perli, S.D., and Lu, T.K. (2013) Tunable and multifunctional
eukaryotic transcription factors based on CRISPR/Cas. ACS Synth. Biol., 2
(10), 604–613.
119 Koleske, A.J. and Young, R.A. (1994) An RNA polymerase II holoenzyme
responsive to activators. Nature, 368 (6470), 466–469.
120 Barberis, A., Pearlberg, J., Simkovich, N., Farrell, S., Reinagel, P., Bamdad, C.,
Sigal, G., and Ptashne, M. (1995) Contact with a component of the polymerase
II holoenzyme suffices for gene activation. Cell, 81 (3), 359–368.
121 Gill, G. and Ptashne, M. (1987) Mutants of GAL4 protein altered in an
activation function. Cell, 51 (1), 121–126.
122 Hope, I.A., Mahadevan, S., and Struhl, K. (1988) Structural and functional
characterization of the short acidic transcriptional activation region of yeast
GCN4 protein. Nature, 333 (6174), 635–640.
123 Ma, J. and Ptashne, M. (1987) A new class of yeast transcriptional activators.
Cell, 51 (1), 113–119.
124 Fields, S. and Song, O. (1989) A novel genetic system to detect protein‐protein
interactions. Nature, 340 (6230), 245–246.
125 Gyuris, J., Golemis, E., Chertkov, H., and Brent, R. (1993) Cdi1, a human G1
and S phase protein phosphatase that associates with Cdk2. Cell, 75 (4),
791–803.