186 9 Small Molecule-Responsive RNA Switches (Bacteria)
Ribozyme An RNA sequence capable of catalyzing a chemical reaction such as
self‐cleavageReferences
1 Nahvi, A., Sudarsan, N., Ebert, M.S., Zou, X., Brown, K.L. et al. (2002) Genetic
control by a metabolite binding mRNA. Chem. Biol., 9 , 1043.
2 Winkler, W., Nahvi, A., and Breaker, R.R. (2002) Thiamine derivatives bind
messenger RNAs directly to regulate bacterial gene expression. Nature, 419 ,
952–956.
3 Mironov, A.S., Gusarov, I., Rafikov, R., Lopez, L.E., Shatalin, K. et al. (2002)
Sensing small molecules by nascent RNA: a mechanism to control transcription
in bacteria. Cell, 111 , 747–756.
4 Serganov, A. and Nudler, E. (2013) A decade of riboswitches. Cell,
152 , 17–24.
5 Sinha, J., Reyes, S.J., and Gallivan, J.P. (2010) Reprogramming bacteria to seek
and destroy an herbicide. Nat. Chem. Biol., 6 , 464–470.
6 Stoltenburg, R., Reinemann, C., and Strehlitz, B. (2007) SELEX – a (r)
evolutionary method to generate high‐affinity nucleic acid ligands. Biomol. Eng,
24 , 381–403.
7 Carothers, J.M., Goler, J.A., Kapoor, Y., Lara, L., and Keasling, J.D. (2010)
Selecting RNA aptamers for synthetic biology: investigating
magnesium dependence and predicting binding affinity. Nucleic Acids Res.,
38 , 2736–2747.
8 Dixon, N., Duncan, J.N., Geerlings, T., Dunstan, M.S., McCarthy, J.E. et al.
(2010) Reengineering orthogonally selective riboswitches. Proc. Natl. Acad. Sci.
U.S.A., 107 , 2830–2835.
9 Nomura, Y. and Yokobayashi, Y. (2007) Reengineering a natural riboswitch by
dual genetic selection. J. Am. Chem. Soc., 129 , 13814–13815.
10 Podolsky, T., Fong, S.T., and Lee, B.T. (1996) Direct selection of tetracycline‐
sensitive Escherichia coli cells using nickel salts. Plasmid, 36 , 112–115.
11 Muranaka, N., Sharma, V., Nomura, Y., and Yokobayashi, Y. (2009) An efficient
platform for genetic selection and screening of gene switches in Escherichia coli.
Nucleic Acids Res., 37 , e39.
12 Topp, S. and Gallivan, J.P. (2008) Random walks to synthetic riboswitches – a
high‐throughput selection based on cell motility. ChemBioChem, 9 ,
210–213.
13 Lynch, S.A., Desai, S.K., Sajja, H.K., and Gallivan, J.P. (2007) A high‐throughput
screen for synthetic riboswitches reveals mechanistic insights into their
function. Chem. Biol., 14 , 173–184.
14 Wieland, M., Benz, A., Klauser, B., and Hartig, J.S. (2009) Artificial ribozyme
switches containing natural riboswitch aptamer domains. Angew. Chem. Int. Ed.,
48 , 2715–2718.
15 Wieland, M. and Hartig, J.S. (2008) Improved aptazyme design and in vivo
screening enable riboswitching in bacteria. Angew. Chem. Int. Ed., 47 ,
2604–2607.