16 4
phosphatase, low or inappropriately normal 1,25-(OH) 2 D, and elevated FGF-23
(Fig. 5.14).- What are the causes of hypophosphatemic rickets/osteomalacia with normal
FGF- 23?
The causes of hypophosphatemic rickets–osteomalacia with normal FGF-23
levels are hereditary hypophosphatemic rickets with hypercalciuria,
Fanconi’s syndrome, and tumor-induced osteomalacia associated with
secreted frizzled related protein 4, FGF7, and matrix extracellular phospho-
glycoprotein (MEPE).
Fig. 5.14 Familial hypophosphatemic rickets–osteomalacia
5 Rickets–Osteomalacia