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30. What are the common RET mutations associated with different variants of MEN
    2 syndrome?

The RET mutations associated with different variants of MEN2 syndrome are

summarized in the table given below.

MEN 2A MEN 2B FMTC

Codon 634 (exon 11) – 85 % Codon 918 (exon

16) – 95 %

Exon 10 and 11

Codon 609, 611, 618, and 620 (exon 10),

codon 630 (exon 11) – 15 %

Codon 883 (exon

15) – 5 %

Codon 768, 790, 791

(exon 13)

Codon 804, 844 (exon

14)

Codon 891 (exon 15)

31. What is the importance of RET mutational analysis in the management of MEN
    2 syndrome?

The RET genotype analysis predicts the aggressiveness of MTC, and this

information is useful in the surgical management of MTC. The different RET

Fig. 11.6 Blubbery lips
and mucosal neuromas in a
patient with MEN2B
syndrome. Note the scar in
the neck after surgery for
MTC

11 Multiple Endocrine Neoplasia